Immune Memory
The Architecture of Immune Memory
Defining T cell exhaustion and the stem-like subsets that sustain immunity in cancer and chronic infection.
Rafi Ahmed, Ph.D.
Professor, Emory University
The Immune-Aging Project is a global non-profit focused on challenges that influence progress across the immune-aging field as a whole.
Laboratories, clinicians, companies, funders, and non-profits all contribute to the advancement of immune-aging science. Many challenges that shape progress are shared across organizations rather than confined to any single one.
These include how knowledge is shared, how evidence is interpreted, and how findings remain useful across time, populations, and technologies.
Our work is organized through two programs:
Science Communication Program. Bringing scientists, evidence, and ideas into structured conversations that broaden the reach of rigorous science.
Continuum Program. Working on the challenges that determine whether immune-aging evidence can accumulate, remain interpretable, and support future translation.
Our outputs are open.
Late-life health loss often attributed to aging is not our inevitable fate. We believe that by elucidating the fundamental mechanisms of immune aging, we can translate that biology into actionable interventions and engineer a future of healthy longevity.
To achieve this, we believe in a community-driven approach. Finding the right collaborator (whether a cross-disciplinary researcher, a funder, or an industry partner) is like finding a substrate for an enzyme.
We aim to facilitate collaborative science and data sharing to help each other overcome bottlenecks in scientific work and bring fundamental science and industry work together.
The Immune-Aging Project is led by scientists with experience spanning aging biology, immunology, and program development.
Executive Director
An aging biologist and engineer whose work combines experimental biology, quantitative analysis, and systems thinking. His research at the Weizmann Institute showed that senescent cells become harder for the body to remove with age, identified a PD-L1-based mechanism that helps them evade immune surveillance, and characterized the diversity of senescent cells that arise naturally in tissues.
Scientific Program Director
An immuno-oncologist at INSERM bridging the gap between cancer biology and aging. Her research at the Weizmann Institute of Science demonstrated that senescent cells hijack the PD-L1 checkpoint to evade clearance, establishing a direct therapeutic link between cancer immunotherapy and longevity science.
In today's world where most of us are focused on making discoveries, along the way we forget the joy as well as the importance of sharing those discoveries not only in our field but with specialists in other fields.
To make this possible, our Science Communication Program brings together new communication formats, emerging scientific communicators, and experienced voices from across the scientific community.
Our evidence-based format for bringing scientific claims, data, and reasoning into the same conversation.
A selective fellowship for emerging scientific communicators who want to shape how rigorous science is communicated across fields and audiences.
Science is an expedition. The Burstcast moves beyond the static presentation to offer a live, evidence-based dialogue. We invite you to witness the "act of finding" as we navigate the data behind the findings, transforming a one-way broadcast into a shared discovery.
We contextualize the inquiry. We begin by bridging the gap between cellular mechanisms and human health, framing the narrative to answer the critical question: "Why does this specific problem matter?"
We define the contribution. The dialogue centers on one distinct, measurable claim: specifying exactly what is new and how this finding resolves a specific gap in our understanding of science.
We explore the key figures live, deconstructing the analytical approach to reveal the evidence and rigor that support the claim.
We open the floor to the ecosystem. A dedicated space for critical dialogue and diverse perspectives, exploring how these findings translate from the laboratory to the real world.
Defining T cell exhaustion and the stem-like subsets that sustain immunity in cancer and chronic infection.
Rafi Ahmed, Ph.D.
Professor, Emory University
Developing mTOR inhibitors to enhance the function of the aging immune system and improve vaccine response.
Joan Mannick, M.D.
CMO, Altos Labs
Human gene therapy of hematopoietic progenitors harnesses the selective advantage to restore a functional immune system.
Alain Fischer, M.D., Ph.D.
Professor, Collège de France
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